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Alpha...2-macroglobulin,...a...multifunctional...binding...protein...with...targeting...characteristics....Current..Issue..October..2016,..30..(10)..Alert..me..to..new..issues..of..The..FASEB..Journal..Submit..Manuscripts..to..TheFASEBJournal..Press..Room..Information..for..Authors..Information..for..Reviewers..Editorial..Board..Editorial..Policies..Subscriptions..Librarian's..Resource..Activate..Online..View..Collected..Papers..Breakthroughs..in..Bioscience..Advertising..Copyright..Permissions..Feedback..FASEB..Publication..Services..Go..to..FASEB..Online.....Cookies..are..required..to..use..this..site...Some..suggestions:..Go..back..to..the..last..page..Go..to..the..home..page......Copyright........2016....by....the....Federation....of....American....Societies....for....Experimental....Biology....Print....ISSN:....0892-6638....Online....ISSN:....1530-6860....DOI:....10.1096/fj.1530-6860.....In...addition,...bioactive...peptides...bound...to...alpha...2M...may...dissociate...in...the...process...of...intracellular...ligand...sorting,...thereby...modulating...cell...function,...or...remain...bound...and...share...the...catabolic...fate...of...alpha...2M....Related....Content....Load....related....web....page....information....Sharing....Email....this....article....to....a....colleague....Facebook....Google+....LinkedIn....Mendeley....Reddit....StumbleUpon....Technorati....Twitter....What's....this?.........Internalized..complexes..may..be..dispatched..into..different..pathways..of..endocytic/lysosomal..pathways..in..a..cell..type-specific..manner...Search....for....related....content....PubMed....PubMed....citation....Articles....by....Borth,....W.....

6...no....Some...suggestions:...Go...back...to...the...last...page...Go...to...the...home...page........Your..browser..doesn't..accept..cookies...The...diversified...and...probably...programmed...binding...functions...of...alpha...2M...indicate...that...in...addition...to...its...role...in...trapping...proteinases,...it...has...other...biological...activities...that...remain...to...be...fully...defined....Alpha....2M....interacts....and....captures....virtually....any....proteinase....whether....self....or....foreign,....suggesting....a....function....as....a....unique...."panproteinase....inhibitor."....Activation....of....alpha....2M....generates....novel....binding....sites,....which....mediate....complex....formation....with....cytokines....and....other....peptides.....15...3345-3353......Abstract...Full...Text...(PDF)...Article...Usage...Stats...Article...Usage...Statistics...Classifications...REVIEWS...Services...Email...this...article...to...a...colleague...Alert...me...when...this...article...is...cited...Alert...me...if...a...correction...is...posted...Similar...articles...in...this...journal...Similar...articles...in...PubMed...Download...to...citation...manager...Citing...Articles...Load...citing...article...information...Citing...articles...via...Google...Scholar...Google...Scholar...Articles...by...Borth,...W....In...human...alpha...2M,...several...reactive...sites...including...high-affinity...sites...for...zinc,...transglutaminase...cross-linking...sites,...and...reactive...sites...derived...from...the...activated...thiol...ester...can...mediate...reversible...or...irreversible...capture...of...proteins...of...diverse...biological...functions....403...Forbidden.......

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